Gut Microbiota Uses the Histone Code to Make Intestinal Cells Speak Their LanguageMarch 19, 2024A growling stomach represents a clear sign that you must eat something tasty; however, sometimes, your digestive system is where the message needs to go! An exciting epigenetics study reveals that our gut microbiota employs a histone code via histone acylations to influence gene expression in intestinal cells, forcing these cells to speak their language! […]
Making a Connection – Lactate Epigenetically Links Metabolism and Gene ExpressionFebruary 19, 2024Falling in love, kicking a football, and cell identity changes driven by metabolic reprogramming all have one thing in common – making a connection is vitally important! Now, a well-hooked-up new study reveals how lactate epigenetically links metabolism to the activation of a gene regulatory network that controls embryonic development. A plugged-in team of researchers […]
One More Reason to Eat Your Wheaties: Your Microbiome and Histone AcetylationFebruary 7, 2023We all know how important it is to eat fiber, whether in the form of fruits and veggies, or even a big bowl of fiber-rich cereal. Now, research from Ben Garcia’s lab (WUSTL) gives us one more reason to eat our Wheaties—our gut microbiome needs it to acetylate histones and possibly ward off diseases like […]
Stat3 is a Mitochondrial Mastermind Behind Metabolic Control of DNA Methylation in Naïve Stem CellsFebruary 15, 2021We’ve seen that mitochondria can modify nuclear DNA methylation, but until recently, the identities of the masterminds behind how the powerhouse of the cell can affect epigenetic change in the nucleus have remained classified. Although Stat3 is most notably recruited by LIF to activate the pluripotency gene network in the nucleus, we also know that LIF […]
