The precise regulation of gene expression is necessary for organismal development, and changes in gene expression regulation underlie many evolutionary adaptations. Defective transcriptional regulation can lead to developmental disorders and disease. Through the combination of novel new technologies, genetics, evolutionary biology, biochemistry, and molecular, cell, and computational biology, many layers of transcriptional regulation have been uncovered and dissected. This meeting will address several of these areas, including basic transcriptional control, enhancer structure and function, chromatin packaging, epigenetics, and phase separation.
- Transcriptional Regulation in Evolution, Development, and Disease