The exact role miRNAs play in gene regulation may be an evolving story but that doesn’t mean you can’t pin down miRNA function in your model system. miRZip anti-miRNA vectors are a new breed of miRNA inhibitors that allow you to permanently knockdown miRNA function so you can analyze changes in phenotype more easily.
Equipped with an H1 promoter, the miRZip anti-miRNA constructs crank out short, single-stranded anti-miRNAs that put their endogenous miRNA targets in a choke hold, inhibiting their function and clearing the way for you to study the regulatory impact of these miRNAs in your studies.
Add Some Stability to your miRNA Knockdown Experiments
The miRZip anti-miRNA constructs were developed using the next generation of self-inactivating-lentiviral vectors so you can put any safety concerns to rest and focus on the number of slick benefits they provide you like the ability to:
- Assault dividing and non-dividing cells for maximum knockdown
- Set up stable cell lines for longer-term experiments (e.g. time course experiments) where you can’t afford “leaky” suppression over time
- Head into in vivo applications, where other approaches just won’t cut it
Head to the Library: miRZip anti-miRNA Pooled Lentiviral Systems
If you’re ready to take your screening to the next level, head to the library format. The miRZip anti-miRNA collection is also now available as a pooled virus library that contains the entire miRZip anti-miRNA collection for high-throughput screening applications.
Check out miRZips in action in: Science, May 2010