eBook: DNA Methylation 2024

DNA methylation, whether in cells or in a cell-free environment, is one of the most powerful and most studied epigenetic regulators of gene expression and genomic organization. This is true for nearly all organisms, leading to the emergence of numerous methods for mapping 5-mC and 5-hmC and other modification states. There are many approaches for studying DNA methylation, with new mechanisms of action being published as quickly as we can keep up, along with streamlined and
potentially more cost-effective means of analysis.
Here we take a look at some particularly interesting recent publications on both the new mechanisms and new methods being reported in this field.

Contents:

cfDNA

Updated cfDNA Nucleosomics Technology Upgrades our Epigenetic Clocks
No Cells? No Problem! How Cell-Free DNA Methylation Profiles May Guide Cancer Management
DNA Methylation Analysis Shows How Cannabis Exposure Increases the Risk of Adverse Health Outcomes

Methods

SIMPLE-seq Collaborates Chemistries to Report Single-Cell 5mC and 5hmC
TIME-Seq Flies When Constructing Cost-Effective Epigenetic Clocks
Differential Methylation Data Are Quick, Easy, and Inexpensive with FML-seq
5hmC Stands Apart from 5mC Through Single-Cell Multi-omic Methods

Late Breaking!

A Selfish, Poisonous Element Could Set the Evolutionary Stage for Genomic Imprinting
EvoETR Epigenome Editor Helps Maintain Cholesterol Levels by Silencing Pcsk9
Pregnancy Epigenetically Ages Mothers – But Breastfeeding May Reverse It