Information loss can drive us crazy – from ruining a potential culinary masterpiece to turning a Lego-building afternoon into a nightmare, but can “losing it” at the epigenetic level drive aging and turn a young whippersnapper into an old fogey? We know all too well about age-related epigenetic changes, and now a team led by […]
- Epigenome
Down the Wrong Path: Trisomy 21 Pushes Neural Progenitors Towards Senescence Profile
Although it sometimes feels like there is no right way to age, intriguing insight from Down Syndrome has given insight into how disrupted nuclear architecture can push us down the wrong path. Down syndrome results from the triplication of chromosome 21 and is a leading cause of intellectual disability. However, Down syndrome is also a […]
Epigenetic Tools and Databases
Tools, where would humankind be without them? The EpiGenie team decided to search out and compile a list of the best tools and databases that epigenetics researchers can’t live without. Here we go: Epigenetic Tools: Data is great! Now go do something with it. Use these data analysis and visualization tools to help decipher your data. […]
Single-cell Multi-omic Maps of Germ Layer Enhancers – Deciphering The Best-laid Body-Plans of Mice and Perhaps Men?
A weekend away with a book of poetry, a mountain biking holiday, or perhaps a daring jewel heist……whatever your idea of a fun weekend is, a well-laid out, precise set of instructions usually help; in short, you need a plan! In the gastrulating mouse embryo, precise epigenomic and transcriptomic instructions dictate the differentiation of pluripotent […]
Know Your Enemy: Understanding Malaria Infection via Epigenome Editing
Sun Tzu’s ancient Chinese military treatise “The Art of War” placed knowing your enemy on a par with knowing yourself when facing battle. These wise words still resound today in the lab of Lubin Jiang (Institut Pasteur of Shanghai, Chinese Academy of Sciences, PR China) where researchers have employed CRISPR/Cas9 epigenome editing to forge a […]