• Cancer Epigenetics
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Resistance is Futile: Epigenetic Therapy Makes Cancer Cells Defenseless

A team of American scientists have shown that an epigenetic therapy might hold promise for combatting drug resistance in cancer. Cancer cells are masters of drug evasion and adept at using alternative pathways to give them an edge during treatment, complicating many therapeutic approaches. Overcoming drug resistance in cancer cells, would save millions of lives […]

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Finding Epimutations in the Genome Haystack

Trying to identify DNA methylation mutations with current technologies usually requires a lot of cells, making it a lot like hunting for a needle in a haystack. Getting down to looking at single cells is becoming possible, but requires you to look at the whole genome, making the hunt for epimutations difficult. Recent work from Silvia […]

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Our Favorite Findings from the Epigenomic Roadmap

For those of you with a keen eye, you’ll have already noticed the mass of Epigenomic Roadmap Studies published in Nature in February. In order to help you navigate this mountain of results we’ve highlighted some of our favorite findings from this collection of papers. Here’s our Top Five Findings: Enhancer-like Elements Take Center Stage in […]

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A cHi-C Way of Capturing Chromatin Conformation

Identifying cancer risk loci is like trying to find a key you lost somewhere in your apartment. You know that it’s there and by combining experience with indistinct recollection you can even narrow it down to a few square meters. Now imagine you not only have to find the key but also map all the […]

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Active Demethylation: TET Enzymes, 5hmC, and Buddies

5hmC was originally discovered way back in the 50’s in bacteriophages and was first observed in mammals in the 70’s, but research into this was set back when these studies failed to replicate. And going back to the future, in 2009 two independent research groups, publishing on the same pages in science, found that this “unknown […]