The English sea captain and politician Sir Francis Drake believed in “sic parvis magna”, or “greatness from small beginnings”. While he hasn’t been around to see the recent explosion in organoid (or mini-organ) research, we are sure he would be impressed. Measuring a few millimeters in diameter and produced via three-dimensional differentiation of stem cells, […]
Ever get that feeling that you forgot something? Well maybe you did, but it doesn't have to be recent epigenetics research if you scope out our Headlines each week.
In today’s loopy world, the wise words “Those who cannot remember the past are condemned to repeat it” have a particular resonance. Thankfully, our epigenomes are dynamic historians that get the message and make use of past transcripts by forming R-loops. R-Loops and the Epigenome R-loops are RNA-DNA hybrids: a 3 stranded nucleic acid structure. […]
We’ve got our mind on methylation and methylation in our mind, but we are often left wondering how DNA methylation got there in the first place. Well, that cognitive tongue twister has now been cracked by a class of RNA that likes to interact with DNA methyltransferases. Extra coding RNAs (ecRNAs) originate from the sense […]
Memories; we all have some we would rather forget, and some that we will hold onto forever. But how exactly is memory formed and what are the biochemical pathways that are in play? Recent studies have indicated that RNA and DNA adenosine methylation are important for the conversion of experiences, both good and bad, into […]
If you’re like many of the researchers we’ve met over the years, you’ve been hoarding some of your favorite Formalin Fixed Paraffin Embedded (FFPE) samples deep in the recesses of a nondescript lab freezer, just waiting to be investigated. We get it; traditionally FFPE samples have been successfully used to analyze RNA and DNA, but […]