Every population has its own unique identity, and behind that is our brain, an organ composed of cellular populations with their own unique DNA methylation identities. However, capturing the true diversity of a population requires the ability to observe each individual in that group and for methylomes that requires innovations in single-cell bisulfite sequencing. In […]
Ever get that feeling that you forgot something? Well maybe you did, but it doesn't have to be recent epigenetics research if you scope out our Headlines each week.
Feeling out of the loop about all the different non-coding RNAs being described? Well hold on, because circular RNAs (circRNA) are about to throw you for a loop. Mammalian circRNAs are created by covalent closure of transcribed exons into loops. These circRNAs are highly expressed in specific brain regions, and conserved between mice and humans. They […]
Tools are great for building, but sometimes it’s more fun using them to break things down. While we’ve applied deactivated Cas9 (dCas9) tools to build our knowledge of DNA methylation, this time it takes an entire toolbox to break the connection between histone methylation and gene repression. This constructive deconstruction comes at you from the […]
In today’s world, where choices are a plenty, alternative is a fashionable choice. When it comes to genomic imprinting, traditionalists swear by DNA cytosine methylation (5mC); however, sometimes imprinting turns to alternative epigenetic marks. Genomic imprinting is typically driven by 5mC at imprinting control regions (ICRs), where it represses the expression of the marked allele […]
It’s not how big it is, it’s what you do with it that counts. Here at Epigenie, we don’t think that size matters, as evidenced by our excitement over studies showing that small RNAs in sperm can mediate huge intergenerational effects related to paternal exercise and diet! Now, a fascinating study from the lab of […]