Four new papers co-published by an international consortium demonstrate and further the clinical potential of epigenetic assays. The series of manuscripts was led by Christoph Bock (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences) and Stephan Beck (University College London). Comparison of DNA Methylation Assays Suited for the Clinic While there […]
Ever get that feeling that you forgot something? Well maybe you did, but it doesn't have to be recent epigenetics research if you scope out our Headlines each week.
A big event always requires a bit of prior preparation, and for evolution, mammalian development is no exception. The mammalian body plans have undergone massive evolutionary rearrangements and diversifications requiring the evolution of complex gene expression profiles. Recent studies in specific tissues in mammalian species have now linked these expression changes to the evolution of […]
One score and six years ago, humanity embarked upon the Human Genome Project (HGP), sequencing all 3 gigabases of our genetic instruction manual. More than 1000 human genomes later, a consortium of synthetic biology heavy-hitters has proposed a new grand challenge. Appending “-Read” to the first project, they now propose Human Genome Project-Write, a quest […]
In the Wild West of CRISPR genome editing, Cas9 has established itself as a wrangler of animal models that takes out any sequence with an sgRNA bounty on its head. But now there’s a new sheriff in town with marksman aim. CRISPR from Prevotella and Francisella 1 (Cpf1) was brought forth by the pioneering lab […]
In the CRISPR hype up to now, DNA has gotten a raw deal. In all known CRISPR systems, RNA guides gang up with protein effectors (e.g., Cas9 and Cpf1) to chop up poor, abused DNA helices. Now, a new CRISPR protein – C2c2 – is giving DNA a reprieve, turning the tables on RNA instead. […]