• Headlines

Ever get that feeling that you forgot something? Well maybe you did, but it doesn't have to be recent epigenetics research if you scope out our Headlines each week.


MicroRNA Isoforms Distinguish Between Breast Cancer Subtypes

Much like the early explorers who set out to find a new trade route to Asia and accidentally stumbled across the Americas, researchers mapping the transcriptome have come across some big surprises. Recently, Isidore Rigoutsos’s lab showed that the expression of microRNA isoforms (called ‘isomiRs’) and tRNAs depends on sex, population, and race. Now, this […]


Stressed Nucleosomes Linked to Depression

Have you ever felt stressed and even depressed? Well, a new study linking stress-induced depressive behaviors to changes in nucleosome positioning suggests that in order to relax yourself, you may first need to relax your chromatin. Susceptibility to major depressive disorder (MDD) depends on genetic variability but also on environmental factors such as a stressful […]


New Reporter System Captures DNA Methylation in Real Time

If a picture is worth a thousand words then surely a video must be worth more? So far, our knowledge about DNA methylation has been limited to a comic strip of static images at different stages. That may all be about to change with a new tool reported by the lab of Rudolf Jaenisch, which […]


Sorting the Old from the New – Cellular Barriers Keeps Stem Cells Young

Alongside smartphones, coffee shops, and bars, we all also need properly functioning stem cells to survive and prosper. Indeed, the stem cell theory of aging posits that the malfunctioning of stem cells in our later years, and not all that caffeine and alcohol, is the major cause of human aging. So how do we keep […]


Microfluidic ChIP Makes a Few Cells Go a Long Way

Chromatin immunoprecipitation (or ChIP) is a handy technique to study epigenetic profiles, but only if you have enough cells. The main problem with ChIP is that it can be a “greedy” technique that uses large numbers of cells while giving back the bare minimum of DNA as a result. This is problematic for the study of genome-wide […]