Histone H3 lysine 4 (H3K4) is one of the most widely studied histone modifications. Acetylation (H3K4me) and various degrees of methylation (H3K4me) of this residue are involved in countless processes. In general, H3K4 modifications are associated with active transcription. Recent research has further characterizes these roles, as well as identified new functions.
This ebook covers the basics of H3K4 modifications, their role in transcription, and their broader significance to development and disease. Assembled here are summaries of various notable studies that examine H3K4 modifications in four board categories.
- Chapter One: Role of H3K4 in Transcription
- Chapter Two: Roles of H3K4 in Stem Cells
- Chapter Three: Cooperation with Other Modifications
- Chapter Four: Role in Disease and Other Phenotypes