During early embryonic development, our genome lets down its DNA methylation defenses and becomes vulnerable to rebellious transposable elements (TEs). However, those rebel scum are quickly met with a barrage of endogenous short interfering RNAs (endosiRNAs), all before they realize even realize that “It’s A Trap!” The mechanism of this cunning tactic employed by our […]
- Stem Cells
Stem Cell Research Headlines
Get all the latest highlights from the literature and special features covering trending stem cell research and applications.
Presumably after a day spent in a local tavern instead of writing and editing verse, the famous Scottish poet Robert Burns noted that “The best laid schemes of mice and men, Often go awry”. However, a new study of genome editing in the embryos of mice and men led by Kathy K. Niakan (Francis Crick […]
While cocktails and embryonic development usually don’t mix well, a cocktail of three transcription-activator-like effectors (TALEs) has just shaken up our understanding of the role LINE-1 retrotransposons during early embryonic development. LINE-1 activation had been considered a consequence of developmental processes, but now a talented team from the lab of Maria-Elena Torres-Padilla at the German […]
It’s not how big it is, it’s what you do with it that counts. Here at Epigenie, we don’t think that size matters, as evidenced by our excitement over studies showing that small RNAs in sperm can mediate huge intergenerational effects related to paternal exercise and diet! Now, a fascinating study from the lab of […]
Decades of diligent exploration in the mammalian genome has led to the discovery that while only around 2% of this base-pair jungle represents protein-coding sequence, over 90% of our genome gets transcribed into RNA species such as long non-coding RNAs (lncRNAs). However, our knowledge base on many lncRNAs remains in “terra incognita” with scant details […]