While it’s never a great idea to stare directly into the sun, a DNA methyltransferase (DNMT) eclipse brought to you by the SunTag system may just steal your eyes during its totality. This designer epigenome editing system comes to you from the labs of Margaret A. Goodell and Wei Li at Baylor College of Medicine […]
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Imagine a world where you could create chromatin loops where and when you want. You’d feel like you’re on cloud nine. Well, get your head out of the clouds, because you’ve got to thank the lab of Kevin Wang at Stanford for targeted and reversible chromatin loop reorganization using deactivated Cas9 (CLOuD9). The CLOuD9 system […]
Tools are great for building, but sometimes it’s more fun using them to break things down. While we’ve applied deactivated Cas9 (dCas9) tools to build our knowledge of DNA methylation, this time it takes an entire toolbox to break the connection between histone methylation and gene repression. This constructive deconstruction comes at you from the […]
Hacking the epigenome is no easy task. Each deactivated Cas9 (dCas9) system boasts its own nuances that must be teased apart before we can crack the histone code with its suite of effector domains. When it comes to histone acetylation, we’ve seen the histone acetyltransferase construct dCas9-p300, which writes H3K27ac to activate gene expression. However, […]
They help organize our schedules, they keep us in touch with good (and bad) friends, and they barely leave our sides throughout the day. But can we exploit the ubiquitous nature of smartphones to facilitate personalized treatment of human disease? This is the hope of researchers from the laboratory of Haifeng Ye (East China Normal […]