Chromatin immunoprecipitation-on-chip (ChIP-chip) is a powerful tool to map target protein DNA binding sites across entire genomes or within biologically important regions such as promoters. This method is used to map chromatin structure and DNA binding sites of transcription factors and polymerases. Roche NimbleGen offers several types of ChIP-chip arrays for a variety of organisms to meet your specific research needs:
- Whole-Genome Designs cover all unique genomic regions in single arrays or multi-array sets and offer unbiased, comprehensive genome coverage for the most complete data sets possible.
- Promoter Designs cover important regulatory regions. Deluxe Promoter arrays offer extensive, single-slide coverage of those regions including gene and miRNA promoters, and CpG islands, while promoter arrays cover only gene promoters.
- Targeted Designs focus on ENCODE regions (up to 30 Mb), promoters of non-coding RNAs or the HOX clusters.
- Custom Designs allow researchers to specify their regions of interest for a fine-tiling approach or design their own targeted probes for a tailored array solution.