Product Overview: Acetylation of histones such histone H4 has been involved in the regulation of chromatin structure and the recruitment of transcription factors to gene promoters. HATs (histone acetyltransferases) and HDACs (histone deacetylases) play a critical role in controlling histone H4 actylation. Histone H4 (acetyl K16) reflects the hyperacetylated stated in histone H4 and strongly correlates with active state of genes. H4 (acetyl K16) is also related to euchromatin and DNA repair, while hypoacetylation of H4(K16) is commonly found in human tumors.
EpiSeeker Histone H4 (acetyl K16) Quantification Kit (Fluorometric) (ab115121) allows the experimenter to measure global acetylation of histone H4-K16 quickly and consistently. The kit is ready-to-use and provides all the essential components needed to carry out a successful assay experiment and it is suitable for specifically measuring global histone H4-K16 acetylation using a variety of mammalian cells including fresh and frozen tissues, and cultured adherent and suspension cells.
View EpiSeeker Histone H4 (acetyl K16) Quantification Kit (Fluorometric) on Abcam’s website