CRISPR-Cas, Zinc Fingers and Epigenetic Editing with Dr. Marianne RotsFebruary 27, 2014Epigenetic Editing is an emerging field that has sparked interest across a number of research groups. By using a fusion of TET we can now target specific genomic regions for demethylation in order to learn about their function and regulation. We got in touch with one of the field’s experts, Dr. Marianne Rots, commissioning editor of Clinical Epigenetics, […]
The New Players in Epigenetic Reprogramming with Dr. Wolf ReikFebruary 3, 2014Dr. Wolf Reik discusses the latest advances in epigenetic reprogramming, and what those new discoveries might lead to. The New DNA Methylation Landscape So it’s become apparent in the last two years, I guess, that there is this process of genome-wide epigenetic reprogramming which occurs naturally in germ cells, early embryo stem cells, et cetera, […]
Webinar: Mechanisms of Epigenetic Regulation in Stem Cells and DevelopmentJanuary 31, 2014Dr. Alexander Meissner discusses the roles of epigenetic mechanisms in stem cells and development. Cytosine methylation in mammals is an epigenetic modification that is largely restricted to CpG dinucleotides and serves multiple critical functions including stable repression of target promoters, maintaining genomic integrity, establishing parent-specific imprinting patterns, and silencing endogenous retrotransposon activity. In somatic tissues, […]
Choline Metabolism, DNA Methylation, and Memory with Dr. Steven ZeiselJanuary 20, 2014Dr. Steven Zeisel discusses how maternal intake of choline effects DNA methylation during development, and can lead to better memory. This interview was shot at the Keystone Symposia’s meeting on Nutrition, Epigenetics and Human Disease, 2013 held in Santa Fe, New Mexico Choline Metabolism, DNA Methylation, and Memory So I’m more and more believing that epigenetics […]
Decrypting Transcription with Dr. Frank GrosveldJanuary 7, 2014Dr. Frank Grosveld points out how little we actually know about the details of transcription and the molecular machinery involved. Transcription Factories We have this loop structure of the genome. And at the same time, we know that every gene that’s being transcribed, that’s active, is part of what we call transcription factories. So […]
Modifying Our View of Histones with Dr. Jerry WorkmanDecember 3, 2013Dr. Jerry Workman discusses the questions surrounding the preservation of histone marks, and the balance between histone turnover and transgenerational inheritance. The Dynamic Histone Code I think one of the most exciting things for me that’s being approached in the field more recently is how are histone marks preserved? We talk about these things carrying […]
The Loose Ends in the Chromatin-Transcription Relationship with Dr. Steven HenikoffDecember 3, 2013Dr. Henikoff discusses some of the gaps in our understanding of transcription and chromatin that still need to be filled in. The Unknowns of RNA Polymerase-Nucleosome Interactions Well, you would think with so much work done on the relationship between transcription and chromatin, the fact that there’s so many meetings on it and all. We […]
Genome Synthesis vs. DNA Methylation: A Battle for One-Carbon with Dr. Patrick StoverNovember 19, 2013Dr. Patrick Stover discusses the competition between genome synthesis and DNA methylation for the use of available folate and one-carbons. The Balancing Act of Folate Metabolism So one of the primary focus of our laboratory is trying to link how changes in metabolism affect specific disease outcomes. And we’re most interested in neural tube defects […]
Long Distance Relationship in the Genome with Dr. Frank GrosveldOctober 24, 2013Dr. Frank Grosveld discusses distal interactions in the genome and how these might be less directed than generally thought. Long Distance Relationship in the Genome Well, I’m most excited about something that I have been working on for a long time. Which is basically how bits of the genome interact with each other. So we […]
Intergenerational Epigenetic Inheritance with Dr. Elizabeth RadfordOctober 22, 2013Dr. Elizabeth Radford discusses some of the latest trends in intergenerational epigenetic inheritance. This interview was shot at the Keystone Symposia’s meeting on Nutrition, Epigenetics and Human Disease, 2013 held in Santa Fe, New Mexico Intergenerational Epigenetic Inheritance We’re collaborating with Mary-Elizabeth Patti who works at Harvard, and she has a mouse model where they undernourish […]