Move Over Caloric Restriction – Hungry-Hungry Histones Slow Aging!May 30, 2023Kick the kebab, bin the burger, axe the avocado toast?! While caloric restriction represents a hunger-inducing yet effective means to extend lifespans, a tasty new study highlights how “hungry-hungry histones” create a neural hunger “state” that slows aging (even when getting our fill), suggesting that growing old may be more delicious than we think! While […]
Tissue Regeneration Rejuvenates Chromatin Age-Domains to Wake Cells from Hyper-quiescenceMay 22, 2023Taking a break from the hectic world now and again might just save your sanity; however, we sometimes need a push to get back up the pace of everyday life! Now, exciting new tissue rejuvenation-based research into the chromatin age-domains associated with hyper-quiescence suggests that aging cells also suffer from this pesky problem. Aging tissues […]
eBook: Epigenetics of Cancer & Disease RiskMay 3, 2023The application of epigenetic approaches to disease research is moving quickly and hundreds of new papers are published every year, from virology to neurobiology and cancer. In this eBook, we present short summaries of interesting discoveries that caught our attention in each of these areas. Table of Contents Chapter 1: Epigenetics in Disease Risk Taking […]
mRNA Shows Its Age and Quiets Down the Immune System with Cap2 MethylationFebruary 14, 2023Wrinkles, gray hair, … Cap2 methylation on mRNA? It turns out that these are all signs of aging. Two elegant new methods to show that Cap1 gets slowly modified to Cap2 as mRNAs age. And just like boomers, they want to live the quiet life, calming down the innate immune system to prevent autoimmunity. Although […]
You Aren’t Going Crazy – Losing It at the Epigenetic Level Really Drives Aging!February 6, 2023Information loss can drive us crazy – from ruining a potential culinary masterpiece to turning a Lego-building afternoon into a nightmare, but can “losing it” at the epigenetic level drive aging and turn a young whippersnapper into an old fogey? We know all too well about age-related epigenetic changes, and now a team led by […]
Chromatin-Con 2023: Epigenetics of Aging Online ConferenceJanuary 19, 2023Our friends and colleagues at Active Motif will be hosting an online conference focusing on the epigenetics of aging. Tune in if you can…Just take a look at the list of speakers and we’re sure you won’t want to miss it! Click over to the Active Motif website for more details and to register: Chromatin-Con […]
eBook: Epigenetics of AgingJanuary 16, 2023Aging and longevity research has moved to the forefront of epigenetics in recent years. From DNA Methylation, to the Exposome and “translational inheritance” we are all avidly interested in this topic. In this eBook we review recent and intriguing research into this topic. Table of Contents Novel Multiomic Epigenetic Clock May Decipher How Epigenetic Aging […]
eBook: Epigenetics & DNA MethylationNovember 21, 2022One of the longest-known and most studied epigenetic markers is DNA methylation, which can regulate gene expression and genomic organization in nearly all organisms. In eukaryotes, the primary modification of DNA is found in cytosines (C), where DNA Methyltransferases mediate the transfer of a methyl group to cytosines, converting them to 5-methylcytosine (5-mC), minor modifications […]
Keeping Aging in LINE by Stabilizing HeterochromatinSeptember 11, 2022Like many aspects of our lives, epigenetic processes can get out of control during aging. Now, exciting new findings have revealed that the secret to keeping our aging epigenomes “in line” is removing LINE-1 RNA from cells, which stabilizes heterochromatin and reverses signs of aging! Previous studies have shown how age-associated heterochromatin loss associates with […]
Novel Multiomic Epigenetic Clock May Decipher How Epigenetic Aging Impacts Cell FunctionAugust 23, 2022Timely advances have demonstrated that significant changes to DNA methylation levels accompany the creaking knees, failing eyes, and changing tastes in music (!) associated with the human aging process. A well-timed study now builds upon these past studies to describe a multiomic-based approach with the potential to forge links between epigenetic aging and the gene […]
