CpG islands have been the best-known tourist destination in the epigenome for a long time, but if you’re looking for a change there’s a destination that all the rage: DNA methylation grand canyons. It is well known that DNA methylation at CpG islands is associated with transcriptional repression. However, the precise molecular mechanism linking DNA […]
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Genome-wide chromosome conformation capture analyses, such as Hi-C, have provided us with snapshots of the large-scale spatial architecture of mammalian genomes, describing chromatin compartments, topologically associating domains (TADs), and CTCF– and cohesin-mediated chromatin loops in many cell types. However, the resolution of Hi-C-based protocols, limited by the size and uniformity of chromatin fragmentation, represents a […]
Nitrous systems, improved aerodynamics, and slick tires on your car may all help to quench your need for speed when you get behind the wheel; however, the need to slow down is just as critical in the world of gene regulation. Recently, a team of researchers has described how the modification of a racy subset […]
A weekend away with a book of poetry, a mountain biking holiday, or perhaps a daring jewel heist……whatever your idea of a fun weekend is, a well-laid out, precise set of instructions usually help; in short, you need a plan! In the gastrulating mouse embryo, precise epigenomic and transcriptomic instructions dictate the differentiation of pluripotent […]
Dr. Ellen Rothenberg from the California Institute of Technology discusses her lab’s research into the epigenetics of T-cell development at the 2019 joint CEEHRC/IHEC meeting.