thought leaders

thought leaders

Get up close and personal with some of the world's top epigenetics and non-coding RNA thought leaders.

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Epigenetics: Getting to Know the Readers and the Writers with Dr. Jerry Workman

May 31, 2013

Dr. Jerry Workman shares some of his thoughts on the next steps in digging into biochemistry of epigenetic mechanisms to understand what’s reading and what’s writing. Epigenetics: Getting to Know the Readers and the Writers I think the most exciting aspect about epigenetics at this time is the potential it provides for some fantastic […]

Dissolving the Layers in Genetics and Epigenetics with Dr. Adrian Bird

May 1, 2013

Dr. Adrian Bird discusses the dissolving barrier between genetics and epigenetics and why he’s cautious about linking epigenetics in heredity. Dissolving the Layers in Genetics and Epigenetics I think what’s most exciting about the field at the moment is that a field called epigenetics is no longer really outside of biology trying to get […]

Looking Under the Hood of Gene Regulation with Dr. Steven Henikoff

April 24, 2013

Dr. Henikoff discusses the next phase in gene regulation research, establishing causality in the gene expression flow and who the key players are. Looking Under the Hood of Gene Regulation The field in general I think has changed,so in just a few years, I think what we’ve seen is that there is much more gettingdown to nitty gritty, what’s underneath the hood, as opposed to the chrome on the top. And that comes through when we begin to understand what the relationship is between starting from a transcription factor causing expressionof a gene, basically causing RNA polymerase to move and what’s the interaction between RNA polymerase and nucleosomes, how that leads to histone modifications, how the histone modifications can help stabilize, for example, the nucleosomes. So these are the questions that we’re sort of beating around the bush and about a couple of years ago, but now I think we’re beginning to understand how it all happens and what the chain of causality is, for example. And also, not just withthe players are but what the interactions are and how it actually works dynamically. So we’d like to think of chromatin in […]

Investigating Long Distance Chromatin Interactions with Dr. Gerd Blobel

April 4, 2013

Dr. Gerd Blobel discusses chromatin organization and the recent technology developments that have deepened our understanding of regulatory domains in the nucleus. Investigating Long Distance Chromatin Interactions So there have been phenomenal developments in our field which address the mechanism of chromatin organization. And I would argue that it’s like in the early days […]

The Epigenetics of Organ Transplantation

January 31, 2013

Dr. Daniel Salomon discusses the state of organ transplants, what obstacles exist, and how epigenetics might be central to improving long-term health in patients. The Challenges in Transplantation My background is in transplantation medicine, transplantation immunology. And my interests are to change the way we manage patients. There’s a huge series of challenges right […]

Splicing up Epigenetics with Dr. Shalini Oberdoerffer

August 23, 2012

Dr. Shalini Oberdoerffer covers the role of splicing in epigenetics, how splicing and DNA methylation affect exon definition and the crosstalk between nucleosome and splicing mechanisms. Splicing Up Epigenetics In the splicing field several years ago, it was a somewhat surprising study coming out of whole genome sequencing studies of ChIP-seq data wherein it […]

Redefining DNA Methylation in Cancer with Dr. Andrew Feinberg

August 1, 2012

Dr. Andrew Feinberg discusses how recent events are reshaping the way his team thinks about DNA methylation in cancer. This interview was shot on campus at Johns Hopkins University. This video was brought to you by epigenetics supporters at EMD Millipore. Redefining DNA Methylation in Cancer Well, there are a number of things I’m […]

Pushing the Technology Frontier in Epigenetics Research with Dr. Andrew Feinberg

July 16, 2012

Dr. Andy Feinberg discusses what technology advances are needed in the field of epigenetics. This interview was shot on campus at Johns Hopkins University. This video was brought to you by epigenetics supporters at EMD Millipore Single Cell Analysis One of the areas I think is going to be really important is single-cell analysis. […]

ChIP Principles and Troubleshooting with Dr. Karen Halls

July 16, 2012

This webinar delivered by Dr. Karen Halls covers and introduction to chromatin and the ChIP process. It reviews protocols for ChIP, antibody selection, optimization of the method and includes troubleshooting guidance.

Single Molecule Epigenetic Analysis with Dr. Paul Soloway

May 15, 2012

Dr. Paul Soloway discusses the limitations with some of the main methods used in epigenetics research and shares a glimpse into what the next generation of tools will look like. This interview took place at the Keystone Symposia’s Epigenomics and Chromatin Dynamics joint meeting in January, 2012. Getting Past ChIP and Bisulfite Applications So, chromatin […]

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