What do the mammalian genome and an old storage unit have in common? They’re both full of so-called junk. But unlike your aunt’s box of glass figurines, the junk in the human genome has turned out to have a lot of value. Most the “junk” in the human genome arose from retrotransposons. Long terminal repeat […]
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Vitamin C in Media Critical for ES Cell 5hmC
Whether its pop culture (like the ongoing royal baby mania) or cell culture, there’s no denying the enormous impact that ‘media’ has on our life. In fact, new evidence shows that a little Vitamin C in cell culture media can influence mouse embryonic stem (ES) cells, like typical pre-teens, to undergo a blastocyst-like identity crisis. […]
DNA and Histone H3K9 Methylation Often Work Alone
Nature is a master of using specific tools for specific jobs, so it’s not too surprising that DNA methylation and SETDB1/H3K9 methylation work on different sets of genes, as University of British Columbia researchers report. But occasionally those tools are more like a Swiss Army knife, like SETDB1, which also methylates H3K9s near endogenous retroviruses […]