SureSelectXT Human Methyl-Seq is the first comprehensive target enrichment system to enable researchers to focus on the regions where methylation is known to impact gene regulation: CpG islands, CpG island shores, undermethylated regions, promoters, and differentially methylated regions (DMRs). SureSelectXT Human Methyl-Seq Uniquely delivers more information than methylation microarrays by detecting individual CpGs Increases throughput […]
- DNA Methylation
5-mC DNA ELISA Kit
The ability to efficiently detect and quantify DNA methylation (i.e., 5-methylcytosine) has become essential for epigenetic-based research. To date, a number of methods have been developed for this purpose including high-performance capillary electrophoresis, bisulfite sequencing, and methylated DNA immunoprecipitation. The 5-mC DNA ELISA Kit is a convenient and powerful tool that allows the researcher to […]
Quest 5-hmC™ DNA ELISA Kit
The Quest 5-hmC™ DNA ELISA Kit is both sensitive and specific and can be used to accurately detect 5-hmC DNA in a variety of samples. The kit is compatible with a wide range of input DNA including intact vertebrate, plant, and microbial genomic DNA, as well as enzyme-digested and mechanically sheared fragments. The Control DNA […]
5-hmC Glucosyltransferase
Specific glycosylation of 5-hydroxymethylcytosine (5-hmC) 5-hmC Glucosyltransferase catalyzes the transfer of a glucose moiety from uridine diphosphoglucose (UDPG) to existing 5-hmC in DNA to form glucosyl-5-hydroxymethylcytosine (glucosyl-5-hmC). 5-hmC Glucosyltransferase does not modify cytosines or methylated cytosines (5-mC). Glucosylation of 5-hmC can be used for sequence-specific, locus-specific, or global quantification of 5-hmC. Validation: 5-hmC Glucosyltransferase was […]
CpGenome™ Human Methylated & Non-Methylated DNA Standard Set
CpGenome™ Human Methylated & Non-methylated DNA Standards are purified from HCT116 DKO cells that contain genetic knockouts of DNA methyltransferases, DNMT1 (-/-) and DNMT3b (-/-) , and have less than 5% methylated DNA. The CpGenome™ Human Methylated DNA Standard has been methylated enzymatically at all CpG dinucleotides by M. SssI methyltransferase 2. These standards are […]