Product Overview:Methylation of histone H3 at lysine 27 (K27) is a mark of gene inactivation and it is thought to mediate heterochromatin formation by forming a binding site for Polycomb. H3 (methyl K27) is also thought to have an important role in the repression of HOX genes during development and in X chromosome inactivation and imprinting. H3 (mono-methyl K27),a modification enriched at pericentromeric heterochromatin, was observed to be broadly distributed throughout all euchromatic sites and participates in silencing gene expression.
EpiSeeker Histone H3 (mono-methyl K27) Quantification Kit (Colorimetric) (ab115068) allows the user to specifically measure global mono-methylation of histone H3-K27 colorimetrically using a variety of mammalian cells including fresh and frozen tissues, cultured adherent and suspension cells.
View EpiSeeker Histone H3 (mono-methyl K27) Quantification Kit (Colorimetric) on Abcam’s website