Product Overview: Methylation of histone H4 at lysine 20 is catalyzed by SET9 and SUV4.20h among other methyl transferases in mammalian cells. H4 (di-methyl K20) has been described as repressive chromatin domain and involved in DNA damage response.
EpiSeeker Histone H4 (di-methyl K20) Quantification Kit (Colorimetric) (ab115095) enables the user to measure global di-methylation of histone H4-K20. The global H4-K20 di-methylation can also be changed by inhibiton or activation of HMTs, making quantitative detection of global di-methyl histone H4-K20 a useful tool for better understanding epigenetic regulation of gene activation/repression. ab115095 is suitable for use with a variety of mammalian cells including fresh and frozen tissues, and cultured adherent and suspension cells.
View EpiSeeker Histone H4 (di-methyl K20) Quantification Kit (Colorimetric) on Abcam’s website