Is it a bird? Is it a plane? No, it’s a “super” new study that combines the strength, ability, and ingenuity of epigenetic editing to shut down our nemesis – the disease-associated dominant mutation – while leaving the innocent bystander allele unharmed! Epigenetic superheroes led by Albert Jeltsch (University of Stuttgart) aimed to battle their […]
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Search Results for: epigenetic editing
Epigenetic Editing Approach Causally Connects Adolescent Alcohol Exposure to Psychiatric Disorder Risk
The modularity of current epigenetic editing technology allows us to evaluate the causality of connections from multiple angles. Now, epigenetic editing in rats using dCas9 activators and repressors has provided a welcome new perspective on how adolescent drinking can induce the onset of psychiatric conditions in adults. Binge drinking during adolescence (a critical period for […]
CRISPRon, CRISPRoff… Two New Tools to Earn You the Black Belt in Hit-and-Run Epigenetic Editing
Power, accuracy, and stability are the three tenets of hit-and-run epigenetic editing that every aspiring black belt must learn to master. To aid our quest, masters from the dojos of Luke Gilbert (University of California, San Francisco) and Jonathan Weissman (Massachusetts Institute of Technology) have come forth with not only new mantra but also a new set […]
Big Things Come in Small Packages: Nanobodies Enter the Epigenetic Editing Ring
While we have seen many contenders for the title of heavyweight champion in the epigenetic editing ring, the adage “big things come in small packages” has taken on a new meaning. Nanobodies, or single-domain antibodies, demonstrate that featherweights can pack an explosive epigenetic editing punch by using their opponents’ momentum against them. Researchers led by […]
Expand Your Epigenetic Editing Portfolio With Targeted RNA m6A Methyltransferases!
For the last few years, DNA has cornered the methylation market as the Apple of epigenome editing tools, but a newly developed CRISPR-Cas13 system has epigenetic investors buying stock in RNA editing! 6-methyladenosine (m6A) is the most abundant RNA modification, and even though we know it’s involved in chromatin accessibility, RNA splicing and repairing damaged […]