While a hit-and-run typically leads to an arrest, in the world of epigenetic editing it turns out to be the key to evading cell cycle arrest (senescence) and promoting the transformation of a law-abiding cell into a cancerous criminal! The hypermethylation of promoters at the wrong time and wrong place is a trademark of cancer, […]
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Search Results for: epigenetic editing
Optogenetic Epigenetic Editing of DNA Methylation Puts You in Control of Stem Cell Fate
In Greek mythology, the fates forge the strings of life that control our lives and choose the moment of its end. We mere mortals yearn for such powers and we are now one step closer to the light thanks to an optogenetic epigenome editing system that lets you write and erase DNA methylation to control […]
An Introduction to Epigenetic Editing with Dr. Marianne Rots
Dr. Marianne Rots, Professor of Molecular Epigenetics and Head of Epigenetic Editing Laboratory at University of Groningen, Netherlands provides an informative overview of the current state of epigenetic editing approaches. Intro to Epigenetic Editing Epigenetic editing exploits the two main characteristics of epigenetics. On the one hand, epigenetic marks are heritable. This means the epigenetic […]
CRISPR-Cas, Zinc Fingers and Epigenetic Editing with Dr. Marianne Rots
Epigenetic Editing is an emerging field that has sparked interest across a number of research groups. By using a fusion of TET we can now target specific genomic regions for demethylation in order to learn about their function and regulation. We got in touch with one of the field’s experts, Dr. Marianne Rots, commissioning editor of Clinical Epigenetics, […]
Epigenetic Editing Targets DNA Demethylation, Induces Gene Expression
TET family proteins grabbed a bit of fame back in 2009 for their role in the demethylation pathway that generates one of our favorite base modifcations 5hmC. Since then, researchers have sought out ways to harness TET’s tremendous potential as a mechanism for active regulation of DNA methylation…if only Miley had followed in its’ footsteps. […]