BayesPeak Analysis Ups Your ChIP-Seq GameOctober 1, 2009Proteins have been binding DNA for some time now, but only recently has ChIP-Seqencing (ChiP-Seq) pointed exactly where. As the technique becomes more popular, more researchers are wondering; what’s the best way to analyze the mounds of data they’ve just created with their ChIP-seq experiments? To tackle this problem, a group of bioinformaticians from the […]
A Tangled Web We Weave When We Practice to RegulateSeptember 10, 2009We’ve all seen them hanging on the freezers and filling otherwise empty wall space in labs–signal transduction maps that look like abstract artwork. They’re enough to make even the most dedicated researcher wonder if there’s light at the end of the tunnel. As difficult as it is to make sense of complex transcriptional cascades, generating […]
miRNA Regulatory Documentary Bonus Footage: Featuring XRN-2September 10, 2009Most miRNA plots we follow share a similar climactic ending: miRNA inhibits this, in this condition, in response to this. Don’t get us wrong. We can read about miRNA regulation all day, which is good because we often do, but do you ever wonder what happens to miRNAs after they’ve locked their target, and put […]
Getting RIPped: miRNA Target ID Workout DeliversSeptember 9, 2009As former bodybuilder turned California Governator, Arnold Schwarzenegger, once said, “Great abs are made in the kitchen…” That may be, but when it comes to epigenetics research, great abs are made by great labs and suppliers, and they’re put to work in immunoprecipitation applications like RIP Chip. Recently, Anke van den Berg and colleagues at […]
Sorting Out Epigenetic Marks NanostyleSeptember 7, 2009Cornell molecular geneticist Paul Soloway wants to know where epigenetic marks coincide – and not just in which patients, or in which tissues, or even in which cells, but on which individual stretches of chromatin. He and co-PI Harold Craighead, an engineering physicist at Cornell, have an Epigenomics Roadmap grant that will help them find […]