New “Recipe” Combines Histone Acetylation, Telomeres, and Mitochondria in a Delicious Scientific Dish!November 26, 2018Assembling tomatoes, mozzarella, and basil into the formidable Insalata Caprese is a straightforward affair and a quick shake, and pour can make tequila, triple sec, and lime juice combine into the sublime margarita cocktail. However, no one has yet managed to fit mitochondrial dysfunction, telomere attrition, and histone acetylation into a dish of data worthy […]
Long Lasting Effects of Trauma in Sperm Long RNAsNovember 21, 2018Long-ing for an explanation for transgenerational epigenetic inheritance via sperm? Well at long last long non-coding RNAs (lncRNAs) are giving us some insight. Studies have shown that sperm DNA methylation and small non-coding RNA (ncRNA) content mediate the transmission of life experience to subsequent generations, especially parental stress. In fact, early life stress is one […]
Getting Personal with Your Blood Methylome: Continuous DNA Methylation Monitoring Anticipates DiabetesNovember 19, 2018In our futuristic world, personalization is a standard. While your watch, phone, and laptop, may be accentuated by personalizations that keep tabs on you, your methylome may not be so lucky. Thankfully, the research group of Michael Snyder has broadcast some insight of the most personal nature from their lab in the city of the […]
How a Histone Deacetylase-Regulated “Kiss” Controls the Timing of Sexual DevelopmentNovember 19, 2018“It started out with a kiss. How did it end up like this? It was only a kiss, it was only a kiss” – The Killers clearly didn’t foresee the consequences of a meeting of lips; however, a new study into the links between nutrition and mammalian sexual development now suggests that a histone deacetylase-regulated […]
If at First You Don’t Succeed, Try, Try Tri-CNovember 13, 2018It’s easy to think that at this point, science has it all figured out. We’ve developed genome-wide techniques to look at chromosome structure in many different contexts: from mapping chromatin interactions (Hi-C), to observing DNA-RNA interactions (SPRITE), and even identifying higher-order DNA structures (GAM). Unfortunately, none of these techniques have the resolution to look at […]