While the crisper drawer of our fridge is the best way to keep our produce fresh, epigenetic editing research now brings forth CRISPR-based manipulation of DNA methylation to keep our crops crisp. This tasty treat comes at you in the form of two new publications from the lab of Steven Jacobsen (UCLA), where the talented team expand […]
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While even a technology with a future as bright as epigenome editing can have its cold day in the sun, the Suntag system has just cleared the clouds over a growing pain of epigenetic editing: the global off-target effects of dCas9-DNMT3A direct fusion constructs. To cure our epigenetic editing blues, the lab of Ryan Lister […]
The call for a rescue operation often makes humanity turn to its latest and greatest tools and equipment. Whether it’s firefighters with water jetpacks or cutting-edge epigenetic editing technology, threats to human kind don’t have it easy these days. In their latest report, the epigenetic emergency response team from the labs of Rudolf Jaenisch and […]
While we’ve been captivated by the powerful applications of precision epigenetic editing via deactivated Cas9 (dCas9), we’ve also been mesmerized by the fact that epigenetic editing doesn’t always work as expected. Building on our need to take a step back and look at the bigger picture, new findings from the lab of Alexander Meissner at […]
While a hit-and-run typically leads to an arrest, in the world of epigenetic editing it turns out to be the key to evading cell cycle arrest (senescence) and promoting the transformation of a law-abiding cell into a cancerous criminal! The hypermethylation of promoters at the wrong time and wrong place is a trademark of cancer, […]