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The Power of Cooperation In Biosynthetic Coculture Systems

July 27, 2015

Traditionally, most bioproduction culture systems use just one strain of yeast or bacteria. Sometimes, though, you just need a little help from your friends. That’s the idea behind the emerging field of synthetic ecology, which just achieved a major proof-of-principle success thanks to a team of MIT scientists. Cocultures have been used in specific cases […]

Optogenetics Sets the Pace

July 8, 2015

When it comes to the fast pace of biotechnology, missing a beat is never good. Building on that principle, a talented team from Israel used optogenetics to resynchronize hearts with just that problem. Optogenetic systems are showing tremendous clinical potential, whether it be bringing eyesight to the blind or restoring excitable physiology, they offer a […]

CRISPR-Display: For the lncRNA Enthusiast that has Everything

July 6, 2015

From wall hung TVs to the latest wearable; displays have been a key technology differentiator for years. Now we’d like to introduce you to CRISPR-Display, one of the latest applications of CRISPR technology for the lncRNA lover that wants to elevate their functional game. Interest in lncRNAs continues to surge, but like other uncharted areas […]

Gene Editing Future Brightens with paCas9

June 22, 2015

We knew it was coming. No, not another Jurassic Park sequel. No, not another installment of Star Wars. More inevitable than the revival of the Terminator franchise: we now have photoactivatable CRISPR/Cas9. Yes, as surely as the sun rises, scientists have developed a way to use that light (or at least the blue part) to […]

MINimize Your Genome Engineering Efforts with CRISPR and Bxb1

May 28, 2015

CRISPR is for genome engineering what Mike Tyson was for boxing: simple, efficient and almost a guarantee to see a knockout in the first round. While in boxing a knockout typically results in an involuntary power nap of the opponent, the phenotype of a gene knockout is often not so clear-cut. Besides potential problems caused […]

None Shall Pass! Genome Editing Stops Heritable Diseases in Their Tracks

May 4, 2015

The scientific world is still reeling from the news of the first genome editing of human embryos to treat genetic disease, as we have reported previously here on Epigenie. Unfortunately, the paper suggested that this strategy may need huge improvement or may never be applicable. However, another recently published study, from the laboratory of Juan Carlos […]

Spray Your Way Free of Cystic Fibrosis with a Gene Editing Nasal Spray

May 1, 2015

With allergy season around the corner, you might be turning to nasal sprays to relieve the symptoms. But now Marie Egan’s lab at Yale University have developed a very different type of nasal spray that helps overcome a disorder much more devastating: Cystic Fibrosis. Earlier attempts to correct the F508del CFTR mutation have been undertaken using CRISPRs in […]

Cas9 Gets an Illuminating Upgrade: Light-activatable Genome Editing

April 30, 2015

While dead Cas9 (dCas9) has been coupled to optogenetic systems to enable on the fly effector domain action, the not so dead Cas9 has just gotten a very different form of light induction that works with genome editing. The designer genome editing system, developed by a talented team from the University of Pittsburgh and the University of North Carolina at Chapel Hill, […]

CRISPR-Cas9 Gene Editing of Human Embryos: A Look at the Science

April 28, 2015

Unless you were on Mars or in the middle of a Netflix binge, you couldn’t have missed the paper that has been hitting the headlines all over the world this week – the first example of the genetic modification of human embryos. The study led by Junjiu Huang (Sun Yat-sen University, Guangzhou) used CRISPR-Cas9 gene […]

CRISPR Goes Back to its Roots to Fight HIV

April 14, 2015

All the cool techniques people are developing with CRISPR-Cas9 are great and all, but sometimes a repurposed natural genetic system just has to go back to its roots. If CRISPR was originally a virus defense system in bacteria, why not forget about all this genome engineering whatnot for a minute and just use it to […]

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