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More Cleavage: CRISPR Cas9 Can Target RNA Too

October 11, 2014

Targeted genome editing using CRISPR/Cas9 has been on the forefront of genome editing research lately. The Cas9 system is effective, efficient, and reliably specific in its approach to cleavage of nucleotides of interest. The catalytic activity of Cas9 depends on its ability to recognize short DNA sequences called the protospacer adjacent motif (PAM). Although it’s […]

Turning the Tables on Bacteria with CRISPR-Cas Antimicrobials

October 11, 2014

Fighting pathogenic bacteria can be as frustrating as being an early adopter of electronic gadgets. You grab the latest smart phone, and the following day leaks of the next generation are hitting the net. The broad-spectrum nature of many antibiotics is partially to blame as they destroy our friendly bacteria and contribute to resistance. Lucky for […]

CRISPR/Cas9 Get Upgraded sgRNA Targeting

August 12, 2014

The Crispr/Cas9 genome editing system has risen to fame so quickly it appears to be suffering from a case of the bends. Researchers at Johns Hopkins University however have just given it a bit more room by to breathe by overcoming an inherent bias that limits sequences the system can target. By modifying the short guide […]

Patient Specific iPSCs Team Up with CRISPR/Cas9

August 12, 2014

Some villains are so tough that it might take a few heroes to take them on. β-thalassemia is just that evil, an all too common genetic disease at the worldwide level. Caused by simple mutations in the hemoglobin beta (HBB) gene, this beast is Mendelian in nature. Which makes a perfect target for CRISPR/Cas9, a duo with […]

Gazing at Your Local Epiproteome with CRISPR-ChAP-MS

August 4, 2014

For those of you who were thinking the CRISPR/Cas9 system was just limited to genome editing, think again because the story just got a new twist. Almost like combining the bullet speed of Superman with the hi-tech gadgets of Batman, Alan Tackett and colleagues come up with a new tool to look at all the […]

Rapid Assessment of CRISPR Genome Editing

August 3, 2014

Well begun is half done. But if you are making a CRISPR knock-out mouse, it is hard to tell early enough whether you’ve begun well. Thankfully, a talented team of researchers in Japan led by Takayuki Sakurai have now optimized an assay that helps you do just that – predict if you are on the […]

The Long and Short of It: ZFNs are Choosey About Repeat Length

August 2, 2014

In a classic switcheroo, a talented research team led by ChongHua Ren inserted a repeat-flanked Zinc Finger Nuclease (ZFN) binding site right in the middle of the transcription factor Gal4, shifting control of Gal4 expression to capricious homologous recombination events. ZFNs edit the genome at specific locations by cutting DNA at the endonuclease site. When […]

Editor in Chief: TALEN, CRISPR and the iPSC Genome

August 2, 2014

Undeniably, the future of therapeutics is moving away from panacea miracle drugs and gravitating towards personalized treatments using gene therapy. Furthermore, the discovery of iPSCs verified the idea that individuals could have their own stem cell line available for therapeutic purposes—therapies that are made possible by editing the genome of iPSCs. Transcription activator-like effector (TALEN) and […]

CRISPR Paves the Way for Large Fragment Genome Editing

August 1, 2014

Traditional large genome editing techniques employ indirect cloning of large genomes into bacterial artificial chromosome (BAC) plasmid. This technique is rather difficult and protracted. Thus, bypassing the BAC plasmid stage in large genome editing would be a big win for the application. The CRISPR-cas9 system, first discovered in Streptococcus pyogenes, is an important tool for […]

Webinar: Using CRISPR/Cas9 Technology for Editing Genes in Haematopoietic Cells and Mice

July 29, 2014

Presented by: Dr Marco Herold, Laboratory Head, Molecular Genetics of Cancer Division, The Walter & Eliza Hall Institute of Medical Research Abstract: The CRISPR/Cas9 technology provides an easy and rapid way to edit genes in vitro and in vivo. Initial experimental strategies utilized a transient transfection approach to modulate genes in vitro, but this proved […]

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