While trying to uncover the mysteries of the DNA methylation, a lot of BS is often required. And no, we’re not talking about workplace politics but rather sodium bisulfite (BS) conversion. Thankfully, the labs of Chun-Xiao Song and Benjamin Schuster-Böckler at Oxford University (UK) have developed a new “BS-free” approach to uncover the secrets of the […]
Keeping up with the rapidly evolving technology landscape for epigenetics and non-coding RNA research can be daunting. Learn more about the available methods out there and stay on top of the latest developments in our Technology section.
Every population has its own unique identity, and behind that is our brain, an organ composed of cellular populations with their own unique DNA methylation identities. However, capturing the true diversity of a population requires the ability to observe each individual in that group and for methylomes that requires innovations in single-cell bisulfite sequencing. In […]
They help organize our schedules, they keep us in touch with good (and bad) friends, and they barely leave our sides throughout the day. But can we exploit the ubiquitous nature of smartphones to facilitate personalized treatment of human disease? This is the hope of researchers from the laboratory of Haifeng Ye (East China Normal […]
Yes, you read that correctly, researchers from the lab of Oliver G. Schmidt (IFW Dresden, Germany) have developed a half-biological, half-mechanical cancer-killing cyborg based on the humble spermatozoa. Specifically, the extremely virile research team loaded sperm with a cargo of chemotherapeutic drugs and provided each wriggler with a specially designed metallic harness to allow magnetic […]
While chromosome conformation capture (3C) methods like single-cell Hi-C focus on coupled pairs of chromosome contacts, and even their promiscuous regions, candid snapshots of chromosomal threesomes have remained an intimate secret … until now. The genomic architects in the labs of Ana Pombo and Mario Nicodemi developed a new method and accompanying statistical model to […]