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Keeping up with the rapidly evolving technology landscape for epigenetics and non-coding RNA research can be daunting. Learn more about the available methods out there and stay on top of the latest developments in our Technology section.

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Epigenetic Editing Targets DNA Demethylation, Induces Gene Expression

November 16, 2013

TET family proteins grabbed a bit of fame back in 2009 for their role in the demethylation pathway that generates one of our favorite base modifcations 5hmC. Since then, researchers have sought out ways to harness TET’s tremendous potential as a mechanism for active regulation of DNA methylation…if only Miley had followed in its’ footsteps. […]

Methylcytosine Makes its Mark on RNA Methylation

November 6, 2013

Methylcytosine – It’s not just for DNA anymore. Despite being almost exclusively associated with DNA for decades, methylcytosine (5mC) has recently been shown to be an important base modification in RNA as well. Exploding interest in the RNA version of 5mC, what it does, and how it works, has been sparked by a sharp uptick […]

A Crash Course in Folate, Nutrition, and DNA Methylation Regulation with Dr. Patrick Stover

October 10, 2013

Dr. Patrick Stover, PhD, the Director of the Division of Nutritional Sciences at Cornell University, provides a great overview of the key role of folate in one-carbon metabolism, and DNA methylation in nutrition. Folate, Nutrition, and DNA Methylation Regulation There’s a long history in the whole field of folate metabolism, one-carbon metabolism, that outcomes […]

Inducible Models Breathe New Life into Epigenetic Inheritance Studies

October 8, 2013

Food, toxins, and stress can all have enormous effects on the epigenome, but pinning down the true epigenetic mechanisms at work is the tricky part. While it’s been difficult to determine mechanisms of action in standard animal models, new ones have been developed using Tetracyline-induced systems, that make it much simpler to tease out how […]

Charting Where Noncoding RNA Transcription Kicks Off

September 24, 2013

While ‘Dark Matter’ is thought to constitute roughly 85% of the cosmos, our genomic dark matter (i.e. noncoding RNAs) makes up an even larger portion (~95%) of our genetic content. Leaving the vastness of outer space to astrophysicists, Dr. Bryan Venters and Dr. Franklin Pugh at Pennsylvania State University focused on creating a map of […]

Webinar: Epigenomics – One Molecule at a Time with Dr. Paul Soloway

September 16, 2013

Dr. Paul Soloway, PhD discusses his latest work on technologies that enable the interrogation of epigenetic marks on a single molecule. **this webinar is no longer available** Epigenomic analyses are used for many applications, including discovering gene regulatory mechanisms; characterizing non-genetic transmission modes of adaptive and disease traits; identifying and detecting disease biomarkers; and for […]

Zymo ChIP DNA Clean & Concentrator™: A New Twist on Chromatin Immunoprecipitation

September 10, 2013

If you’re one of those researchers who has been avoiding ChIP experiments like the plague because of the aggravating low yields and poor quality ChIP DNA associated with traditional ChIP protocols, then it’s time to give the ChIP DNA Clean & Concentrator™ (ChIP DCC™) Kit from Zymo Research a whirl. The ChIP DCC™ is a […]

One Man’s Junk DNA is Another’s Intronic microRNA

September 3, 2013

Introns have a bad rap these days. Sequestered with the rest of the (epi)genome in the term ‘junk’ DNA’; A reductionist way of describing 95% of our beloved genome as useless. But as new evidence keeps pointing out, introns and ‘non-coding’ regions actually code for most of the genomes products and/or function. In recently published […]

RRBS and 450k Arrays Face Off Over DNA Methylation Analysis

August 27, 2013

DNA methylation has been a cornerstone of epigenetics research from the start, and the emergence of technologies that make investigation of the modification more accessible has only made the DNA methylation field even hotter. Several tools and techniques are available to assess DNA methylation levels, but two in particular, reduced representation bisulfite sequencing (RRBS) and […]

Webinar: Life Long Changes in DNA Methylation & ncRNAs in Fetal Alcohol Syndrome (FAS)

August 22, 2013

Western University’s Ben Laufer (Ph.D. Candidate) discusses how bioinformatic software was used to establish that even moderate exposure to alcohol during pregnancy, equivalent to a few beers every now and then, can produce profound and heritable variations in development, behaviour, and learning that are maintained in the exposed fetus for a lifetime by altered epigenetic […]

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