Being “caught in the act” isn’t usually a good thing, but catching DNA methyltransferases in the act is a very good thing for epigeneticists. A team at the University of Southampton (U.K.) now reports that they have developed a reproducible, real-time fluorescent assay that will help scientists understand how these enzymes regulate themselves, interact with […]
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To “B-cell” Or Not To “B-cell” – DNA Methylation & Stem Cell Fate
We doubt that Shakespeare was thinking of DNA methylation and stem cell differentiation when he penned that famous line, and yet somehow it seems to apply here. Recent work led by Frank Rosenbauer at the Max Delbrück Center for Molecular Medicine in Berlin has revealed some of the first insights into the causal relationships between […]
Epigenetic Cancer Therapy – Not Just for DNA Anymore
Researchers studying cancer epigenetics therapies dream of days when we might be able to control DNA methylation like our car stereos…less treble, little more bass. 5 Aza is one of the early leaders in the epi pipeline, and like a lot of therapeutics out there, we learn more about how it impacts other cellular processes […]
Vidaza® and Entinostat Combo; A Potential Lung Cancer Therapy
Some things always seem better in combos: beer & pizza, SpongeBob & square pants… Soon, we may need to add Vidaza® & entinostat to that list. At the recent American Society of Clinical Oncology annual meeting, researchers from Johns Hopkins Medical Institute and the Lovelace Respiratory Research Institute reported that the combination of Vidaza® (5-azacitidine) […]
Promoter Targeted Small RNAs Lay a Big Smack Down on Gene Expression.
Sometimes to get the correct result, a researcher needs to knock a gene down. Not just a little knockdown, but like a Mike Tyson knockdown! (well, at least back in the days before the whole ear-biting thing.) Some clever scientists at The Scripps Research Institute may have found a way to do just that. By […]