Product Overview: Methylation of histone H3 at lysine 36 seems to be coupled to the proces of active transcriptional elongation and it is enriched towards the 3′ end of target genes. However, when present within protein-coding regions it prevents inappropriate transcriptional initiation of intragenic sequences. H3 (mono-methyl K36) is commonly found together with H3(di-methyl K27) […]
- Histone Methylation Kits and Assays
EpiSeeker Histone H3 (pan-methyl K27) Quantification Kit (Colorimetric)
Product Overview: Methylation of histone H3 at lysine 27 has an important role in transcription repression and it is catalyzed by G9a and Polycomb Groups enzymes such as EZH2. H3 (mono-methyl K27), a modification enriched at periocentromic heterochromatin, is broadly distributed throughout all euchromatic sites and participates in silencing gene expression. H3 (di-methyl K27) and […]
EpiSeeker Histone H3 (tri-methyl K27) Quantification Kit (Fluorometric)
Product Overview: Methylation of histone H3 at lysine 27 has an important role in transcription repression and it is catalyzed by G9a and Polycomb Groups enzymes such as EZH2. In particular, H3(try methyl K27) is a facultative heterochromatin mark, which promotes the recruitment of polycomb group proteins for gene silencing. Increased global histone H3 (tri […]
EpiSeeker Histone H3 (pan-methyl K4) Quantification Kit (Fluorometric)
Product Overview: Methylation of histone H3 at lysine 4 by Methyl transferases such as SET1, SET7/9, MLL and Trx among others occurs in mammals in several distinct genomic distributions. In mammals, H3(mono-methyl K4) is associated with silenced euchromatin regions whereas H3(di-methyl K4) and H3(tri-methyl K4) is associated with transcriptionally active euchromatin regions. EpiSeeker Histone H3 […]
EpiSeeker Histone H3 (methyl K4) Assay Kit (In Situ)
Product Overview: Methylation of histone H3 at lysine 4 by Methyl transferases such as SET1, SET7/9, MLL and Trx among others occurs in mammals in several distinct genomic distributions and may serve as a global epigenetic mark in euchromatin. H3 (methyl K4) also appears to have an inverse correlation to allele-specific DNA methylation. EpiSeeker Histone […]