Product overview: Methylation of histone H3 at lysine 4 (K4) is thought to be a global epigenetic mark in euchromatin and a mediator of activated transcription. In mammalian cells, several SET-domain containing histone lysine methyltransferases such as MLL1 are responsible for adding one, two or three methyl groups at lysine 4 of histone H3. EpiSeeker […]
- Abcam
EpiSeeker Histone H3 (K9) Methyltransferase Activity Quantification Assay Kit
Product overview: Methylation of histone H3 at lysine 9 (K9) mediates heterochromatin formation by forming a binding site for HP1 and also participates in silencing expression at euchromatic sites. In mammalian cells, histone lysine methyltransferases such as SuVar39h and ESET among others are responsible for methylation of lysine 9 at histone H3. EpiSeeker Histone H3 […]
EpiSeeker Histone H3 (K27) Methyltransferase Activity Quantification Assay Kit
Product overview: Methylation of histone H3 at lysine 27 (K27) is a mark of gene inactivation and it is thought to mediate heterochromatin formation by forming a binding site for Polycomb. In mammalian cells, the EZ family group of proteins among others are responsible for the addition of one, two or three methyl groups at […]
EpiSeeker Histone H3 (K4) Demethylase Activity Quantification Assay Kit
Product Overview: Methylation of histone H3 at lysine 4 (K4) is thought to be a global epigenetic mark in euchromatin and a mediator of activated transcription. H3(K4) demethylation is regulated by KDM1/LSD1, which can remove di- and mono-methylation from H3(K4), and the JARID proteins such as RBP2 which catalyzes the removal of methylation through a […]
EpiSeeker Histone Demethylase KDM1/LSD1 Inhibitor Assay Kit
Product Overview: KMD1/LSD1 (Lysine Specific Histone Demethylase 1) is a histone demethylase that only acts on mono- or di-methylated lysines. KDM1/LSD1 acts as a co-repressor by mediating demethylation of H3(meK4), a specific tag for epigenetic transcriptional activation. EpiSeeker Histone Demethylase KDM1/LSD1 Inhibitor Assay Kit (ab113456) allows the user to measure inhibition of KDM1/LSD1. The kit […]