HpaII Methyltransferase DNA Methyltransferase Enzymes and Assays - New England Biolabs HpaII Methyltransferase recognizes the same sequence as the MspI Methyltransferase, but modifies the internal cytosine residue (C5) of the sequence CCGG. View HpaII Methyltransferase on New England Biolabs’s websiteQuestions About This ProductName* First Last Email* QuestionDate MM slash DD slash YYYY PhoneThis field is for validation purposes and should be left unchanged.Δ