SET7 Methyltransferase methylates lysine 4 (Lys 4) of histone H3. Methylation occurs at the e amino group of lysine residues. Di- and tri- methylation of histone H3 Lys 4 is a hallmark of transcriptionally active chromatin and is globally distributed.
- DNA Methyltransferase Enzymes and Assays
PRMT1 Methyltransferase
PRMT1 is a major protein arginine methyltransferase. It specifically methylates arginine 3 (Arg 3) of H4 in vitro and in vivo. Furthermore, methylation of histone H4 at Arg 3 facilitates transcriptional activation by nuclear hormone receptor. Ordered cooperative functions of PRMT1, p300 and CARM1 in transcriptional activation by p53 is observed on the GADD45 gene […]
MspI Methyltransferase
MspI Methyltransferase recognizes the same sequence as the HpaII Methyltransferase, but modifies the external cytosine residue (C5) of the sequence CCGG.
MspI Methyltransferase
MspI Methyltransferase recognizes the same sequence as the HpaII Methyltransferase, but modifies the external cytosine residue (C5) of the sequence CCGG
Human DNA (cytosine-5) Methyltransferase
Dnmt1 methylates cytosine residues in hemimethylated DNA at 5’…CG…3′. Mammalian Dnmt1 is believed to be involved in carcinogenesis, embryonic development and several other biological functions . The b4k of the methylation takes place during DNA replication in the S-phase of the cell cycle.