MspI Methyltransferase DNA Methyltransferase Enzymes and Assays - New England Biolabs MspI Methyltransferase recognizes the same sequence as the HpaII Methyltransferase, but modifies the external cytosine residue (C5) of the sequence CCGG. View MspI Methyltransferase on New England Biolabs’s websiteQuestions About This ProductName* First Last Email* QuestionDate MM slash DD slash YYYY PhoneThis field is for validation purposes and should be left unchanged.Δ