PRMT1 is a major protein arginine methyltransferase. It specifically methylates arginine 3 (Arg 3) of H4 in vitro and in vivo. Furthermore, methylation of histone H4 at Arg 3 facilitates transcriptional activation by nuclear hormone receptor. Ordered cooperative functions of PRMT1, p300 and CARM1 in transcriptional activation by p53 is observed on the GADD45 gene following ectopic p53 expression and/or UV irradiation.
View PRMT1 Methyltransferase on New England Biolabs’s website- PRMT1 Methyltransferase