While even a technology with a future as bright as epigenome editing can have its cold day in the sun, the Suntag system has just cleared the clouds over a growing pain of epigenetic editing: the global off-target effects of dCas9-DNMT3A direct fusion constructs. To cure our epigenetic editing blues, the lab of Ryan Lister […]
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Search Results for: epigenetic editing
dCas9-Tet1 to the Rescue: Maintained DNA Demethylation of Fragile X Syndrome Neurons
The call for a rescue operation often makes humanity turn to its latest and greatest tools and equipment. Whether it’s firefighters with water jetpacks or cutting-edge epigenetic editing technology, threats to human kind don’t have it easy these days. In their latest report, the epigenetic emergency response team from the labs of Rudolf Jaenisch and […]
TET Proteins: Defending Differentiation by denying de novo Methylation!
I don´t overeat! I’m not lazy! I’m not eating the agar plates when I´m working in the lab late, honest! Psychologists consider denial as one of our most primitive defense mechanisms and recent studies of epigenetic defense mechanisms in embryonic stem cells (ESCs) by the labs of Olivier Elemento (Weill Cornell Medical College) and Danwei […]
dCas9-Dnmt3a-Dnmt3L Methyltransferase Seeds a Nuclear Reaction
Some scientific breakthroughs are so transformative that there’s no containing their spread once they’ve seeded. By engineering cellular nuclear reactions with a biochemical twist, the most powerful deactivated Cas9 (dCas9) methyltransferase explodes from the lab of Tomasz Jurkowski at the University of Stuttgart. The free energy of this reaction forges not only a new tool […]
How Fatty Acids Alter the Epigenome
It’s is easy to blame our parents and their epigenetics whenever we’re struggling to squeeze into our summer swimwear, but a brand new study illustrates how our own dietary choices have a big impact on health. A team from Lund University have shown just how eating fatty acids is not only bad for your waistline, […]