We have to make a lot of decisions in our lives, but sometimes when given two choices, going with both can be the right answer. For example, researchers working on neurodevelopment figured out two different phenomena that regulate non-CG methylation in the postnatal brain, but how are they connected? Now, Harrison Gabel’s lab (Washington University […]
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Search Results for: epigenetic editing
RNA Methylation and DNA Demethylation Teamwork Make the Transcriptional Dream Work
Dream teams come in all shapes and sizes, from the 1970 Brazil football team to the Mercedes F1 team of the 2010s. A new epigenetic alliance formed between RNA methylation and DNA demethylation recently made its competitive debut and now shows how teamwork makes the dream work! A synergistic team led by Dongxin Lin, Jian […]
NANOG’s Prion-like Behavior Builds Bridges to Pluripotency
In both the literal and figurative sense, building bridges can really get you places! Knowing this, genome engineers and epigenetic architects recently created a blueprint demonstrating how a pioneer transcription factor – NANOG – uses prion-like behavior to form gel-like protein condensates that create interstrand DNA “bridges” to reorganize chromatin and clear a rapid path […]
Like a RedChIP to a Bull! – New Technique Explores RNA-Protein-DNA Interactions
The publication of a new technique is like waving a red rag to a bull for many in the epigenetics arena. Now, “RedChIP” has us stampeding in anticipation towards the exploration of the complex interactions taking place between RNA, DNA, and proteins in the nucleus. Olé! Non-coding RNAs (ncRNAs) interact with proteins and DNA to […]
Automated Chromatin Profiling Platforms Autopilot Patients to the Clinic
From human-free supermarket check-outs to autopiloted cars, the modern world is rapidly moving towards automation. In the most recent advance, a rabble of robotic researchers has applied related technological tricks to epigenetic assays to “autopilot” high-throughput chromatin profiling and provide a clinical tool that may support optimized treatment choices in leukemia patients. Specifically, a technology-driven […]