Sun Tzu’s ancient Chinese military treatise “The Art of War” placed knowing your enemy on a par with knowing yourself when facing battle. These wise words still resound today in the lab of Lubin Jiang (Institut Pasteur of Shanghai, Chinese Academy of Sciences, PR China) where researchers have employed CRISPR/Cas9 epigenome editing to forge a […]
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Search Results for: epigenetic editing
Visualizing CRISPR-Cas9 Genome Editing: Seeing is Believing!
Many studies have put their faith in CRISPR-Cas9 as a means to edit genes in human embryos, to fight HIV, and to explore epigenetic regulation. However, if you are someone who really needs to see CRISPR-Cas9 in action to believe it, an epic new study has you covered! So, cast away those doubts and qualms, […]
dCas9 Epigenome Editing Toolbox Smashes Histone Methylation Dogma
Tools are great for building, but sometimes it’s more fun using them to break things down. While we’ve applied deactivated Cas9 (dCas9) tools to build our knowledge of DNA methylation, this time it takes an entire toolbox to break the connection between histone methylation and gene repression. This constructive deconstruction comes at you from the […]
Reporter of Genomic Methylation Delivers Imprinting and Epigenome Editing Insights
Here at EpiGenie we like to think of ourselves as reporters of genomic methylation, but two new studies from the lab of Rudolf Jaenisch at MIT give us a run for our money and demonstrate the utility of their reporter of genomic methylation (RGM). Using RGM, the talented group brings forth a deeper understanding of […]
Tuning Chromatin Microenvironments with Epigenome Editing
Ensuring the sustainability of our environment is a noble goal, and when it comes to the chromatin microenvironments epigenome editing is no exception. While we’ve seen a range of epigenome editing applications, the long-term (mitotically stable) nature of these modifications has remained a challenge. In 2002, epigenome editing demonstrated that when it comes to the […]