The call for a rescue operation often makes humanity turn to its latest and greatest tools and equipment. Whether it’s firefighters with water jetpacks or cutting-edge epigenetic editing technology, threats to human kind don’t have it easy these days. In their latest report, the epigenetic emergency response team from the labs of Rudolf Jaenisch and […]
- Pluripotent Stem Cell
SunTag Casts Light on iPSC Reprogramming
While the DNA editing function of CRISPR/Cas9 systems may appear to hog the limelight, we believe that a new SunTag approach for CRISPR/Cas9-mediated induced pluripotent stem cell (iPSC) reprogramming via epigenome editing deserves its day in the sun! The exciting reprogramming strategy utilizes an endonuclease dead Cas9 (dCas9) fused to a repetitive protein scaffold known […]
CLEVER Technique Maps the 5-Formylcytosine Landscape during DNA Demethyation
Mapping an undulating, dynamic, and partially hidden landscape represents a vexing problem to say the least, especially when the landmarks of interest are rare DNA demethylation by-products in a single cell! This is the task faced by those intrepid explorers hoping to map the genome-wide location of 5-formylcytosine (5fC), a fleetingly rare oxidized form of […]
Mapping mRNA Methylation in the Mouse: From ESCs to the Brain
As Ptolemy and other noteworthy cartographers will tell you, a detailed and up-to-date map is always useful. This navigational tool has guided many intrepid explorers from familiar regions towards the unknown with the promise of discovery and adventure! In the linear world of ribonucleic acid (RNA), intrepid researchers have mapped the locations of the N6-methyladenosine […]
Top Upcoming Stem Cell Conferences
Conferences are ideal places to hear insights from the leaders in your field, to watch the up-and-comers present their new and exciting visions, and to network with potential collaborators (i.e., drink and eat and have some fun!). To assist you with these endeavors, EpiGenie brings you the pick of the bunch: some of the most interesting stem […]