Since their debut with tiling microarrays back in 2005, DNA methylation affinity reagents have rapidly become a weapon of choice for prepping samples for genome-wide methylation studies. In the last few years enrichment methods have evolved almost as rapidly as the technology platforms on which they’re analyzed. Let’s take a look at some of the […]
Keeping up with the rapidly evolving technology landscape for epigenetics and non-coding RNA research can be daunting. Learn more about the available methods out there and stay on top of the latest developments in our Technology section.
For the pipette-jockeys out there who have been toiling away with tedious bisulfite sequencing runs, MS-PCR, or Me-DIP protocols: Hang in there! It looks like help might soon be on the way. A group of Oxford researchers just published a method that uses nanopore technology to sequence single molecules of DNA, including 5-methylcytosine, all without […]
The miRNA target prediction field has developed rapidly over the last few years. New entrants like miRanda, PicTar, DIANA, and RNA22 have acted as oracles to the target seeking research community, but have often left scientists with more questions than answers, so experimental validation is still required. Taking advantage of the fact that Arognaute-mediated mRNA […]
DNA, it has turned out, isn’t all it was wound up to be. In recent years we learned that the molecule of life, the discovery of the 20th century, did not-could not-by itself explain the huge differences in complexity between a human and a worm. Forced to look elsewhere, scientists turned to RNA; however, methodological […]
As a post-doctoral fellow in 1997, Karolin Luger burst onto the chromatin scene with the now classic Nature cover story, “Structure of the nucleosome core particle at 2.8 Å resolution” [Nature 1997, 389, 251−260]. A native of Austria, Dr. Luger joined the faculty at Colorado State University in 1999, where she is an HHM Investigator. […]