If you’re underperforming at work, you might end up with a rejected paper, failed experiments, or an angry boss. However, this isn’t so bad when compared to how mutated DNMT3A underperforms in its role as a DNA methyltransferase, since that can result in a pathogenic overgrowth known as Tatton-Brown-Rahman syndrome (TBRS). Despite DNMT3A’s known role […]
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Search Results for: dnmt
dCas9-Suntag-DNMT3A Outshines the Off-Target Effects of Direct dCas9-DNMT3A Fusions
While even a technology with a future as bright as epigenome editing can have its cold day in the sun, the Suntag system has just cleared the clouds over a growing pain of epigenetic editing: the global off-target effects of dCas9-DNMT3A direct fusion constructs. To cure our epigenetic editing blues, the lab of Ryan Lister […]
Intergenerational Transmission of Dad’s Diet: Dnmt2 Provides a Big Payload of Small RNAs
Dnmt2 represents the lesser-known child of the DNA-methyltransferase family, but not because of any lack of pizazz or stage presence, but perhaps due to the lack of detectable DNA-cytosine methylation activity when compared to its more well-known brethren (Dnmt1 and Dnmt3). Instead of modifying DNA, Dnmt2 plays a big role in transfer RNA (tRNA) methylation […]
Epigenetic Editing Misses the Mark: dCas9-DNMT3A Causes Off-Target Genome-Wide DNA Hypermethylation
While we’ve been captivated by the powerful applications of precision epigenetic editing via deactivated Cas9 (dCas9), we’ve also been mesmerized by the fact that epigenetic editing doesn’t always work as expected. Building on our need to take a step back and look at the bigger picture, new findings from the lab of Alexander Meissner at […]
dCas9-SunTag-DNMT3A Causes a Total Methylation Eclipse
While it’s never a great idea to stare directly into the sun, a DNA methyltransferase (DNMT) eclipse brought to you by the SunTag system may just steal your eyes during its totality. This designer epigenome editing system comes to you from the labs of Margaret A. Goodell and Wei Li at Baylor College of Medicine […]