A little redundancy can be a good thing. A team of researchers led by Dr. Kevin Morris at the Scripps Institute, in La Jolla, recently showed that a little redundancy in the regulation of PTEN, a tumor suppressor gene, can be pretty useful…but also really complicated. PTENpg1, a PTEN pseudogene, regulates PTEN via both sense […]
- "lncRNA"
Search Results for: lncRNA
Epigenetic Regulators (miRNAs, lncRNAs) Get Regulated Epigenetically
With Halloween coming up, perhaps it is fitting that the authors of two recent papers describe a “tangled web” of epigenetic regulations. In one paper, researchers suggest that DNA methylation and perhaps other epigenetic modifications disrupt long non-coding RNA (lncRNA) activity. In the other paper, a different team shows that DNAm messes with the miRNA […]
Chromatin Altering Enhancers Help Genes Escape lncRNA Silencing
This holiday season, you may not be able to escape the big family dinner table, and the aunts and uncles that drink too much and bring up old arguments. But researchers at Temple University report that some genes can escape from the stranglehold of silencing that long noncoding RNAs (lncRNAs) impose. And they do it […]
Gut Microbiota Uses the Histone Code to Make Intestinal Cells Speak Their Language
A growling stomach represents a clear sign that you must eat something tasty; however, sometimes, your digestive system is where the message needs to go! An exciting epigenetics study reveals that our gut microbiota employs a histone code via histone acylations to influence gene expression in intestinal cells, forcing these cells to speak their language! […]
XIST’s X-istential Crisis: A New Role in Autosomal Gene Regulation
The long non-coding RNA (lncRNA) XIST functions as an epigenetic silencer tightly linked to the X chromosome to balance gene expression between the sexes; however, this lncRNA now has a cause for concern as an autosomal gene regulatory function just pushed XIST into a full-blown “X-istential” crisis! Reports have described a dispersed XIST configuration in […]