Most epigenetic studies are music to our ears, but do you prefer “The Rolling Histones,” “Run-5mC,” or something more classical while working in the lab? Well, move over rock and hip-hop, as an epigenetic masterpiece now describes how a long non-coding RNAs (lncRNA) epigenetically conducts a synaptic symphony to “orchestrate” fear extinction memory. Previous pleasant-sounding […]
- "lncRNA"
Search Results for: lncRNA
Dnmt3bas Is Inactive Dnmt3b’s Nemesis, Keeping Its Levels Low via Transcription and Splicing
The main character of many movies has a memorable nemesis who can’t help but try to bring them down and get in their way. Now, it turns out that the nemesis of the inactive Dntm3b isoform may just be development’s best friend. Before differentiation, Dnmt3b transcript levels are kept low, but get a boost at differentiation. […]
Online Learning: Rinnformatics – Genome Informatics Classes for Everyone
If you’ve ever wanted to develop informatics skills to analyze sequencing data, but weren’t sure where to start, then we have the place for you! We found this fantastic resource built by Dr. John Rinn and his lab at the University of Colorado – Boulder. It’s a free, online series of courses that give you […]
Active DNA Demethylation as a Source of DNA Damage at Enhancers
Paint a self-portrait, build a house? If, instead, your more achievable New Year’s resolution was to be more active, new and exciting findings on how the abundance of single-strand DNA breaks (SSBs) at neuronal enhancers represents an intermediate of active DNA demethylation will be right down your alley! Researchers led by Wei Wu and André […]
Can Engineering Chromodomains Take Histone Methylation to “Affinity” and Beyond!?
The troupe of “toys” we use to explore the world of histone methylation just gained a new friend thanks to a playful team of epigenetic engineers who have taken histone modification-reading chromodomains to “affinity” and beyond! Researchers led by Gianluca Veggiani (Louisiana State University, USA) and Sachdev Sidhu (University of Waterloo, Canada) knew that histone-modification […]