With temperatures soaring above 100°F in many parts of the U.S., it can be awfully hard to remember what last winter was like. But thanks to histone modifications, many plants have a built-in memory of cold periods—which is important for flowering. Plants not only remember that they went through a cold period, but they also […]
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ENCODE and Roadmap Epigenomics Antibody Validation Database
Many epigenetics techniques and projects rely on high-quality antibodies, but not all commercial antibodies perform well enough to get the job done. On top of that, there’s no uniform standard, or easy steps to fully validate a good antibody. With help of the Park lab at Harvard Medical School, there is now a place that […]
Automated Epigenetics: Diagenode’s SX-8G IP-Star Compact System
After slaving away all day at the bench just to run a handful of epigenetic assays, you’ve probably wished that there were some sort of robot around that could do most of the work for you. Now, Diagenode’s SX-8G IP-Star Compact Automation System turns that fantasy into a reality. The IP-Star Compact instrument harnesses the […]
Hitting the (Hair Dye) Bottle May Alter DNA Methylome
If you change your hair color more frequently than Lady Gaga, you may be affecting your DNA methylation patterns, according to a new study in the journal Epigenetics. To gain a better understanding of the “normal” human methylome, researchers used BeadChip arrays to analyze the methylation of 26,486 CpG loci in the blood of 205 […]
DNA and Histone H3K9 Methylation Often Work Alone
Nature is a master of using specific tools for specific jobs, so it’s not too surprising that DNA methylation and SETDB1/H3K9 methylation work on different sets of genes, as University of British Columbia researchers report. But occasionally those tools are more like a Swiss Army knife, like SETDB1, which also methylates H3K9s near endogenous retroviruses […]