RNA Immunoprecipitation (RIP) is growing up. After suffering through some awkward adolescent years, RIP has evolved from its humble beginnings in a few hardcore labs and is now stepping out shadow of its more famous cousin, Chromatin Immunoprecipitation (ChIP). The more mature RIP has been steadily building its fan base too with curious researchers seeking […]
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Histone Mods? There’s an App for That
Although they’re better known for robust histone “abs”, the folks up at Millipore have now demonstrated that they’re not too shabby at cranking out solid histone “apps” as well. The team just released an iPad® app that’s a really slick, interactive resource for histone modifications available, absolutely free in iTunes. Why waste time on Angry […]
Sperm Nucleosome Retention is All Off Base
There are lots of ways sperm cells are different from other cell types, but a new PLoS Genetics paper focused on one way in particular, chromatin structure, in order to find out what those differences mean and where they come from.In most cells, DNA is packaged up into nucleosomes, but in sperm, nucleosomes are only […]
Nickel Exposure Takes Its Toll Via H3K4me3
It’s been known for a while that nickel-based compounds are linked to cancer. In fact, if we had a Nickel for every time we hear about how dangerous nickel exposure is, well, we might be able to buy a cup of coffee (Nickels just aren’t worth what they used to be!). But the point is, […]
Chromatin States Get On the Map
Deciphering chromatin status across an entire genome must seem like trying to navigate through an Amazon rain forest without a guide. Luckily, new work just published begins the process of creating chromatin state roadmaps to help point epigenetics researchers down the right path. To make that journey a little smoother, a research group from MIT […]