CUT&Tag-IT™ Assay Kit Overview Cleavage Under Targets and Tagmentation (CUT&Tag) is a method to investigate genomic localization of histone modifications and some transcription factors that reveals interactions between proteins and DNA or identifies DNA binding sites for proteins of interest. Unlike MNase-Seq or ATAC-Seq methods that target open chromatin and are therefore dependent on chromatin […]
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PIXUL™ Multi-Sample Sonicator
PIXUL™ Multi-Sample Sonicator Overview Next-generation sequencing applications, such as ChIP-Seq, RNA-Seq, RIP-Seq, exome sequencing, and whole genome sequencing require precise sample fragmentation (200-600 bp) for compatibility with short read sequencing platforms. Shearing by physical sonication, as opposed to enzymatic methods, is preferred for its unbiased nature and ability to produce a relatively narrow fragmentation profile. […]
LightSwitch™ lncRNA Promoter Products
Long noncoding RNAs (lncRNAs) have been shown to play important roles in the regulation of both transcription and chromatin organization. But, the promoters of lncRNA genes appear to be regulated differently than those of protein-coding genes. The LightSwitch Luciferase Assay System makes it fast & easy to study lncRNA promoter regulation using the same materials […]
Tag-ChIP-IT® Kit
The Tag-ChIP-IT® Kit offers a method to perform chromatin immunoprecipitation (ChIP) on transcription factor sequence variants, mutations and truncations without the need for protein-specific antibodies. Simply create an expression construct containing the protein of interest in-frame with a C-terminal AM-tag. Active Motif’s unique AM-tag sequence is specifically designed to work in ChIP. It has minimal […]
Cas9 Monoclonal Antibody
Cas9 is a nuclease from Streptococcus pyogenes that can be targeted to particular DNA sequences through a guide RNA that results in double-stranded breaks in DNA. Cas9 is part of the CRISPR/Cas9 gene-editing system that can create a DNA break at a specific location with the genome. CRISPR (clustered regularly interspaced short palindromic repeat) is […]