Scientific News, Technology, and Product Information
Analyze open chromatin regions at genome-wide scale. ATAC-Seq is a rapid assay that allows analysis of epigenetic profiles across the genome by identification of regions that have open or accessible chromatin states. Because of the assay’s speed, simplicity, and applicability to a wide range of sample types, ATAC-Seq has become a commonly-used epigenetic assay, and […]
Maximize retainment of limited ChIP-Seq samples When performing ChIP-Seq on limited samples, maximizing retainment of the already precious sample is key. Active Motif’s Low Cell Optimization Module enables Low Cell ChIP-Seq Kit users to monitor sample retainment as they progress through the protocol. This first-of-its-kind module includes “positive control” samples and antibody, as well as […]
Perform ChIP on FFPE samples Formalin-fixed paraffin-embedded (FFPE) clinical samples are a valuable resource for retrospective research. However, working with FFPE samples presents a challenge for epigenetics techniques such as ChIP. Active Motif has leveraged its epigenetics expertise to develop commercially available kits to enable ChIP from FFPE tissue for use in Next Generation Sequencing […]
One of the biggest challenges associated with preparing high quality ChIP-Seq libraries is sample loss. Traditional library preparation methods require multiple end-repair and ligation steps which contribute to loss of material. To overcome this challenge, Active Motif has introduced its TAM-ChIP technology to perform chromatin immunoprecipitation and next-generation library preparation at the same time. TAM-ChIP […]
Active Motif’s new Low Cell ChIP-Seq Kit offers a complete ChIP-Seq workflow using as few as 1,000 to 50,000 cells per chromatin preparation. This surpasses the limitations of traditional ChIP-Seq protocols which often require more than 100,000 cells for sample preparation. With Low Cell ChIP-Seq, limited sample material, difficult to culture cell lines and small […]
