5-Hydroxymethylcytidine (5-hmC) Antibody (pAb)

Whereas a large body of evidence exists regarding the existing form of methylation, very little is yet known about 5-hydroxymethylcytosine methylation. 5-methylcytosine is converted into 5-hydroxymethylcytosine by the TET family of cytosine oxygenases, but little is known about the role of 5-hydroxymethylcytosine in the cell. Many tools exist to study 5-methylcytosine, but few are able to discriminate 5-hydroxymethylcytosine from 5-methylcytosine. Our 5-Hydroxymethylcytidine antibody has been extensively tested and validated in methyl DNA immunoprecipitation (MeDIP), immunofluorescence, immunohistochemistry and dot blot. It also recognizes 5-hydroxymethylcytosine present in either single stranded or double stranded DNA.