Our day-to-day experiences provide a clear understanding of cause-and-effect; a lab mate’s birthday means cake for lunch, and cake for lunch means hours of hard work in the gym! While this cake-centric concept might be simple and easy to follow, the seemingly straightforward causal relationship between DNA demethylation and the upregulation of gene expression, much […]
- "epigenetic editing"
Search Results for: epigenetic editing
CRISPR-EChO Amplifies the Sound of Silent Chromatin
Hello heterochromatin, my old friend; CRISPR has come to edit you again; And echo in the sound of silence. As reported in a resounding new study, CRISPR-EChO comes at you from the lab Stanley Qi (Stanford University, California) and amplifies the sounds of silent chromatin. Following on from avant-garde studies describing CRISPR-GO and CasDrop, which […]
Supersizing Crops by Demethylating RNA – A New Way to End World Hunger?
While supersizing meals has helped to expand the waistlines of many a human “couch potato,” a seriously sumptuous new study has established that RNA demethylation induced via the expression of the human RNA demethylase FTO in potatoes results in a supersizing that could help end world hunger. The transformation of exogenous and endogenous genes has […]
New Single-cell CRISPR Screens “ATAC” Chromatin Accessibility
Have you been struggling to agree on a plan of action for your recent epigenetic experiments? Have you been fighting over just what strategy to use to decipher how genetic alterations affect the epigenetic landscape? While we should all follow John and Yoko’s example and try to give peace a chance, you sometimes need to […]
dCas9-dMSK1 Provides the Potent Power of Programmable Histone Phosphorylation
Time to move over histone methylation, the potent activating power of programmable histone phosphorylation joins the dCas9 epigenome editing toolbox and shows how it takes histone acetylation along for the ride. A rather active team of researchers led by Isaac B. Hilton (Rice University, Houston, TX, USA) knew that phosphorylation represents one of the most […]